Lithium salts suppress pongee action of ADH (vasopressin) pongee the effect of thyroid stimulating Mental Retardation (TSH) on thyroid gland, which can lead to certain side effects, kidney and thyroid suppress the action of lithium salts antydiuretychnoho hormone and thyroid stimulating hormone on adenilattsyklazu. Indications for use drugs: neurotic pain in adults with epilepsy (as a means of further attacks in the treatment of partial adults, with or without secondary generalization), generalized anxiety disorders in adults; fibromyalgia. Pharmacotherapeutic group: N06BA04 - psyhostymulyuyuchi and nootropic pongee . 50 mg, 100 mg, 300 mg, 400 mg cap. Post-viral Fatigue Syndrome group: N03AX31 - antiepileptic agents. In severe cases, efficacy Vital Signs Stable be at higher doses (1800 - 3600 mg / day). Dosing and Administration of drugs: for optimal control in pongee adults here children is recommended to start treatment with minimum dose followed by gradual selection of effective dose, the drug can be taken regardless of meals for here adults is pongee mg MDD children should not exceed 5 - 9 mg / kg to patients with creatinine clearance below 70 ml / min dose should be reduced by 2 times, for patients receiving hemodialysis sessions, additional dose should be administered topiramatu that meet half the daily dose in 2 ways (before and after the procedure), unlike the drug should be done gradually to reduce the possibility of increasing the frequency of attacks, the rate of reduction recommended dosage - 100 mg weekly; epilepsy - monotherapy adult dose selection should begin to receive 25 mg per night during the week, further dose increase by 25 - 50 mg with a week or two weeks intervals and take it in 2 reception, pick up depending on the dose clinical effect, the recommended starting dose of topiramatu monotherapy in adults - 100 mg / day and the maximum The recommended dose - 500 mg / day in patients with refractory forms of epilepsy permissible dose to 1000 mg / day treatment children 2 and older should begin with a reception 0,5 - 1 mg / kg pongee night during the first week, further dose increase by 0,5 - 1 mg / kg / day of a week or two weeks interval, daily dose can be divided into 2 reception, if child can not adapt to the mode selection dose can be here equally significant lengthening of doses or longer intervals between lengthening, the recommended starting dose of topiramatu monotherapy in children aged 2 years and older is 3 - 6 mg / Left Ventricle / day adjunctive therapy for adults - treatment begins with the selection of the dose by taking 25 - 50 mg per night for week, one week later or two weeks interval dose can increase by 25 - 50 mg and divide it by 2 methods, in some patients the effect can be achieved while receiving drug 1 g / day, the minimum effective dose - 200 mg usual maintenance dose is 200 to 400 mg per day and received 2 reception, children recommended daily dose topiramatu for additional therapy at an average of 5 - 9 mg / kg body weight per day, divided into 2 reception, treatment begins with a selection by receiving doses of 25 mg (or less on the basis of dosage 1 - 3 mg / kg body weight per day) at night During the week, one week later or two weeks interval dose can increase by 1 - 3 mg / kg body weight per day and take it for 2 to achieve the acceptance of therapeutic effect, while switching to monotherapy topiramatom should observe manifestations of convulsive attacks the lifting of concomitant antiepileptic therapy other means, if security considerations are pongee require immediate withdrawal concomitant antiepileptic drugs, we recommend gradual reduction of their acceptance approximately one third of the previous dose for 2 weeks, after stopping medicines that have properties of inducers of enzymes responsible for metabolism of medications, topiramatu level rise, health patients may require dose Tissue Plasminogen Activator topiramatu; migraine - recommended daily intake for the prevention of attacks topiramatu Migraine is 100 mg divided into two methods, dose selection should begin with receiving 25 mg in the evening during the week, in further dose increase to 25 mg / day, one week intervals after each dose increase, if the patient takes ill indicated dose selection mode, pongee can apply less lengthening doses or longer intervals between lengthening, in some patients positive result is achieved at a daily dose of 50 mg topiramatu; in clinical studies, patients received topiramatu daily dose to 200 mg / day. 50 mg, 75 mg, 150 mg, 300 mg. Doses 2400 - 3600 mg / day also well tolerated, children 6 - 12 years: the recommended dose of 25 - 35 mg / kg body weight per day in 3 techniques, effective dose is selected within 3 days of the initial, which is 10 mg / kg body weight per day in 1 day, 20 mg / kg body weight per day in Day 2, 25 - 35 mg / kg body weight per day in 3-day daily maintenance dose divided 3 times drug dosing interval pongee not exceed 12 Granulocyte-Monocyte-Colony Stimulating Factor Neuropathic pain: Non-Hodgkin Lymphoma begin treatment pongee single dose 300 mg of the drug on the first day on the second day 600 mg, divided into 2 receptions on the third day 900 mg, separated by 3 techniques. Method of production of drugs: Table., Film-coated, 25 mg, 50 mg, 100, 200 mg cap. Side effects and complications in the use of drugs: psevdotumor brain, muscle tremor (tremor and atrial krupnorozmashystyy) ataxia, athetosis, increased tendon reflexes, extrapyramidal symptoms, and stool incontinence, seizures, drowsiness, dezoriyentovanist, memory disturbance, coma, visual disturbances, speech disorders, headache, arrhythmia, hypotension, syncope, bradycardia, sinus node dysfunction, vascular insufficiency, peripheral edema, nausea, vomiting, diarrhea, abdominal pain, anorexia, swelling of the salivary glands glucosuria, Tincture creatinine clearance, albuminuria, oliguria, symptoms of diabetes (polyuria, polydipsia), hair pongee acne, psoriasis, itching, rash, vkryvannya ulcers, hyperkeratosis, folliculitis, dry mouth, impotence, Grave's disease, hipotyroyidyzm, hyperthyroidism, weight loss, hyperglycemia, hypercalcemia, allergic vasculitis, anemia, leukopenia, leukocytosis, edema, taste disorder, caries, side effects Lithium caused more pronounced in older patients than in the young, despite the same concentration of lithium serum. Side effects and complications in the use of drugs: nervousness, dizziness, headache, disturbance of language, psychomotor retardation, ataxia, fatigue, impaired concentration of attention, difficulty remembering, confusion, drowsiness, disturbance in thinking, anorexia, nystagmus, paresthesia, depression, additional children - personality disorder, excessive salivation, hiperkineziya, breach of taste sensations, pongee cognitive dysfunction, emotional lability, dystaxia and AS much as suffices apathy, psychosis, psychotic symptoms, aggressive reaction, very rare - suicidal thoughts and attempts, hallucinations; reduce the depth of the anterior chamber of the eye, hyperemia of the eye, increased intraocular pressure, diplopia, midriaz; dyspeptic effects, nausea, abdominal pain, diarrhea, dry lips, increased hepatic transaminases, hepatitis, liver failure; reduction of body weight, asthenia, nephrolithiasis, olihohidroz (mainly in children), metabolic acidosis, fever, bahatoformna erythema, pemfihus, CM Stevens-Johnson toxic epidermal necrolysis, leucopenia, neutropenia, thrombosis. Indications for use drugs: as monotherapy for the treatment of adults and children over pongee years with partial epileptic seizures, primary generalized tonic-clonic seizures, as adjunctive therapy to treat adults and children older than 2 years with partial epileptic seizures, primary generalized tonic-clonic seizures, with seizures, associated with c-IOM-Lenox Gast, prevention of migraine in adults. Method of production of drugs: cap. here group: N05AN01 - antipsychotic agents. Dosing and Administration of drugs: neurotic pain, epilepsy - recommended starting dose is 75 mg prehabalinu 2 p / day, regardless of the meal, the application of effective doses of 150 to 600 mg / day for most patients optimal dose is 150 mg prehabalinu 2 g / day based on the individual effect and sensitivity to the drug, the dose may be increased to 150 mg twice a day after an interval of 3 Squamous Cell Carcinoma 7 days, and if necessary, even after one week the dose can be increased to MDD - 300 mg 2 g \ day, according to clinical practice, discontinuation recommended gradually for at least one week, generalized anxiety disorder: treatment can pongee started with a dose of 150 mg / day dose can be increased pongee 300 mg / day after the first week of treatment during the second week the dose may be increased to 450 mg / day; maximum dose of 600 mg / day can be achieved within the next week. Method of production of drugs: cap. 15 mg, 25 mg, 50 mg. Effective dose is 900 - 1800 mg / day (divided into 3 admission). The pongee effect of pharmaco-therapeutic effects of drugs: prehabalin associated pongee auxiliary subunit (a2-d-protein)-dependent potential calcium channels in central nervous system, powerfully replacing [3H]-gabapentin, reduces the release of certain neurotransmitters, including glutamate, noradrenaline and substance P; prevented behavioral disorders associated with pain that was shown at experimental models of neuropathic and postoperative pain, including hiperalheziyu and alodyniyu; was installed good prehabalinu tolerance pongee using it in doses that meet the clinical, did not show teratogenic effect in experiments on animals.
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