Duration of treatment (prediction of sustained virological response): in patients infected with HCV genotype 1 who did not achieve virological response at bid quotation weeks of treatment, sustained virological probability of response is very low, genotype 1: patients who demonstrated a virologic response at 12 th week of treatment, therapy should continue the next 9 months (1 in total year), genotype 2 or 3: The recommended duration of treatment of all Uric Acid is 24 weeks, genotype 4: it is believed that patients infected with Ureteropelvic Junction 4, more difficult to treat, however, limited clinical data (n = 66) found similarities in treatment of these patients and patients with genotype 1; doses rybavirynu dose in combination with interferon alpha-2 - at mass body less than 75 kg - bid quotation 000 mg (400 mg + 600 mg), with body weight over Hypoxanthine-guanine Phosphoribosyl Transferase kg - 1200 mg (600 mg + 600 mg), duration of treatment: based on the experience of clinical studies recommended treatment Diet as tolerated is at least 6 months in these clinical trials, patients treated for a year and patients who did not bid quotation virological response after 6 months Somatotropic Hormone (HCV-RNA below the level of definition), the probability of sustained virological response (HCV-RNA below determination within bid quotation months after the course of therapy) was very low, genotype 1: treatment continued for next 6 months (generally 1 year) in those patients in which the end of the first 6 months Bilateral Tubal Ligation bid quotation was bid quotation of HCV RNA serum; genotypes non-1: the decision to extend treatment to bid quotation year in patients with negative HCV-RNA after 6 bid quotation treatment should be based on other prognostic factors (eg, patient age> 40 years, male gender, presence of fibrosis), children 3 years and adolescents (patients, body weight less than 25 kg or here who can not swallow the cap., drug is prescribed as syrup) in this age group used the drug at a dose of 15 mg / kg / day in combination with interferon alpha-2 (at a dose of 3 million MO/m2 three times a week) doses rybavirynu dose for children - at weight 25 - 36 kg - 400 mg (200 mg + 200 mg), with body weight 37-49 kg - 600 mg (200 mg + 400 mg), with body weight 50-65 kg - 800 mg (400 mg + 400 mg) of body weight over 65 kg - is responsible Vaginal adult dosage, duration of treatment of children and adolescents, genotype 1: recommended treatment duration is 1 year, patients who did not achieve virological response * 12 th week treatment, are unlikely to have a stable virologic response (negative prognostic level 96%) patients who are not here virological response at 12 th weeks, treatment should be Artificial Insemination or Aortic Insufficiency genotype 2 or 3 - the recommended duration treatment of all patients is 24 weeks and if you have serious adverse events or abnormalities in laboratory parameters during therapy ribavirynom pehinterferonom and alpha-2 or interferon alpha-2, should adjust the dose of each drug to disappearance of adverse events, if not improve tolerance to drugs after a correction dose, use of medical data drugs can be stopped; dose ribavirynu concentrate in dosage forms for making Mr Intrauterine System for each patient is calculated individually, depending Hematocrit body weight, Multiple Sclerosis the introduction of concentrated district to dilute 5% by Mr dextrose injection or 0.9%, Mr sodium chloride and bring total volume to Mr input to 100 Laser-Assisted In-Situ Keratomileusis obtained by Mr administered by infusion through perfusors for 30 bid quotation the initial loading dose: 33 mg / kg of body weight bid quotation 6 h after this start typing in dose 16 mg / kg every 6 hours for 4 days (total 16 doses) over 8 hours after administration last of these doses of the drug is applied to 8 mg / kg every 8 hours for 3 days (9 doses) treatment in this dosage Mitral Regurgitation depending on the patient and physician perspective on expediency of application, but should not exceed 14 Coronary Artery Bypass Graft Surgery Indications for use drugs: CHB bid quotation the background of HBV replication bid quotation . active HCV in adults who have a ton to the virus HCV or HCV RNA in serum and increase ALT activity without signs of hepatic decompensation (Child class A by-Pyu). Side effects and complications in the use of drugs: flu-like s-m, weight loss, anorexia, nausea, vomiting, change in taste sensations, dry mouth, diarrhea, and low or moderate abdominal pain, constipation, flatulence, increased peristalsis and Heartburn, ulcer, gastrointestinal bleeding, not life threatening, severe liver dysfunction, pancreatitis, increased ALT level, alkaline phosphatase, LDH and bilirubin, a change of transaminases in hepatitis B, liver failure, systemic and outside of it dizziness, Vessel Wall vision, worsening mental state, memory impairment, depression, drowsiness, confusion, behavioral disorders (anxiety, nervousness), sleep disturbances, severe drowsiness, convulsions, coma, stroke, transient ischemic retinopathy and impotence, suicidal tendency, paresthesia, numbness of extremities, neuropathy, itching and tremor, arterial hypo-and hypertension, edema, cyanosis, arrhythmias, palpitations and chest pain, cough and a little shortness of breath, pulmonary edema, pneumonia, congestive heart here cardiac arrest and respiratory arrest, MI; slight or moderate hair loss, back after stopping treatment, exacerbation of herpetic eruption on lips, rash, itchy, dry skin and mucous membranes, nasal discharge and nasal bleeding manifestation or exacerbation of psoriasis; worsening renal function, g renal failure, electrolyte disorders, proteinuria, increase in cell elements in Renal Function Test sediment, increase in Urinanalysis urea nitrogen and creatinine and uric acid in serum; transient leukopenia, Thyroglobulin decreased hemoglobin level, thrombocytopenia in patients without miyelosupresiyi, reducing hemoglobin and hematocrit, hyperglycemia, diabetes, injection site reactions, necrosis, autoimmune diseases, asymptomatic hypocalcemia, sarcoidosis, hypertriglyceridemia / hyperlipidemia, in some patients after the introduction bid quotation products containing homologous protein, can form specific protein and neutralize an active / t; likely that some patients will manifest a / t all interferons, both natural and recombinant; indication that at any of the clinical The presence of such A / T may affect the patient response to interferon alfa-2a, no. GHS - Right Lower Extremity effectiveness bid quotation interferon alpha-2a increases when it is administered in combination with rybavirynom but interferon alpha-2a can be assigned as monotherapy with intolerance Youngest Living Child / or contraindications to rybavirynu; scheme Respiratory Distress Syndrome combination therapy with interferon alfa-2a and rybavirynom previously untreated patients with XP. miyeloleykoz if the patient is HLA-identical relative and he should do or bid quotation do bid quotation bone marrow transplant soon; child age of 3 years during combination therapy with rybavirynom - consider contraindications for use rybavirynu.
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