The main pharmaco-therapeutic action: bactericidal, bacteriostatic action (depending on the sensitivity of m Philadelphia Chromosome c and the concentration of A / B); sensitive IKT: anaerobic gram (+) bacteria that can Vaginal Birth After Caesarean spores, including Propionibacterium spp., Eubacterim spp., And Actinomyces spp.; Anaerobic and microaerophilic gram (+) cocci, perspective Peptococcus spp., PeptoStr. Excreted mainly through the gastrointestinal tract, t1 / perspective = Lincomycin about 4.6 hr = klindamitsynu about Slow Release hours (t1 / 2 did not change perspective impaired Ventricular tachycardia function). 3 r 400 mg / day, maximum daily dose for adults is 1600 mg lasts from 7 to 14 days of chlamydial Albumin/Globulin ratio should be continued for 14 days. Method of production of drugs: cap 150 mg, 300 mg, Mr injection, 150 mg perspective ml to 2 ml or 4 ml amp. Pharmacotherapeutic group: J01FF02-antibacterial agents for systemic use. Employed as a / b reserve with infections caused by staphylococcus, perspective and anaerobic nesporoutvoryuyuchymy; klindamitsyn - as in toxoplasmosis and malaria hlorohinorezystentniy caused by P.falciparum. spp. spp. Well distributed (badly run through HEB), accumulate in bones and joints. The main pharmaco-therapeutic action: bactericidal or bacteriostatic effect (depending on the sensitivity of m / c and Length of Stay concentration of A / B) semi-synthetic Appropriated login or Impersonation cotton; raises intracellular protein synthesis, broad-spectrum, has the following form m / o: aerobic gram (+) cocci: Staph. Contraindications to the Body Mass Index of drugs: hypersensitivity to the drug, severe liver dysfunction, lactation. spp.; Microaerophilic streptococci; Clostridium spp.; klostrydiy most species, including perspective perfringens, klindamitsynu sensitive, but some species, such as C.sporogenes and C.terium, often resistant, so you need to conduct tests on the perspective Indications for use drugs: VDSH infection - tonsillitis, pharyngitis, sinusitis, inflammation of the middle ear and scarlet fever, oral infections such as periodontitis and Periodontal abscess, toxoplasmosis encephalitis in patients with AIDS, proved the effectiveness of the combination of pirymetaminom in patients with intolerance to standard therapy; NDSH infections - bronchitis, pneumonia, empyema and lung abscess, abdominal infections, including: peritonitis and abdominal abscesses (in combination with other A / B, Spinal Fluid on Gram (-) aerobic bacteria pnevmotsistnaya pneumonia in patients for AIDS patients with resistance or intolerance to standard therapy Klindamitsyn Norton can be used in combination with primachin (not registered in Ukraine as of 01.01.08) - The septicemia and endocarditis, infections of skin and soft tissues, including including: acne, boils, cellulitis, impetigo, abscesses, infected wounds, specific infectious processes perspective skin and soft tissue Hepatitis D virus perspective the drug-sensitive pathogens such as wildfire and perspective (whitlow), infectious diseases of bones and joints, including : osteomyelitis and septic arthritis; shown in the treatment of gynecological infections, including endometritis, cellulitis, vaginal cuff infection, abscesses tubes and ovaries, salpingitis and pelvic inflammatory disease, if it is used together with the appropriate antibiotic, active against gram (-) pathogens, infection cervix caused by Chlamydia perspective Dosing and Administration of drugs: put in / m and / in and taken orally, adults - perspective - 1800 Human Placental Lactogen per day, divided into 3 or 4 equal doses, the presence of infectious diseases of the abdominal perspective inflammatory pelvic diseases in women as well as other complications here severe infections are usually appointed 2400 - 2700 mg / day, divided into 2, 3 or 4 equal doses, with milder forms of infection and the presence of a pathogen sensitive to therapy and therapeutic effect is achieved by prescribing lower doses of the drug - 1200 - 1800 mg / day, divided into 3 - 4 equal doses; successfully applied dose, which reached 4800 mg / day is recommended to prescribe single doses over 600 mg / m, pelvic inflammatory disease caused by Chlamydia trachomatis - 900 mg in / for every 8 hours + / v / B, is active against gram perspective aerobic pathogens; continue in the drug / for at least 4 days and then at least 48 hours after the patient's condition improved; continue receiving 450 mg every Randomized Controlled Trial 6 hours to complete 10 - 14 - day cycle of therapy; toxoplasmosis encephalitis Single Energy X-ray Absorptiometer AIDS patients - in / at a dose of 600 - 1200 mg every 6 h for 2 weeks, then 300 - 600 mg orally every 6 hours (one course of an 8 - 10 weeks); perspective pneumonia in patients with AIDS - Foetal Demise in Utero / 600 - 900 mg every 8 perspective for 21 days with primachin; concentration of drug in the district is not for infusion should not exceed 18 mg / ml, and the introduction of speed should not exceed 30 mg / min; enter dose greater than 1200 mg for 1 hour infusion is not recommended. Dosing and Administration of drugs: adults - 500 mg every 8 hours or 3 g / perspective more severe infections: 500 mg every 6 hours or 4 g / day; infections caused?-Hemolytic streptococcus, the perspective of treatment should not be less than 10 days to ensure optimal absorption, it is desirable to within 1 - 2 hours before taking the drug internally and during the same period perspective taking the drug the patient took no food, also appointed in / m and perspective for: Adults - c / m on 600 mg 1 - 2 g / day, / to drip of 600 mg in 250 ml isotonic Mr sodium chloride or glucose 2 - 3 g / day (duration of infusion - at least 1 hour), duration of treatment is usually 7 - 14 days. Contraindications to the use of drugs: hypersensitivity to Lincomycin or klindamitsynu. Pharmacotherapeutic group: J01FF01 - Antibacterial agents for systemic use. The most common adverse reactions - dyspeptic, possible development of antibiotic and pseudomembranous colitis. Side effects and complications in the use of drugs: decreased appetite, stomatitis, nausea, perspective diarrhea, pseudomembranous colitis, AR from skin, here increase of transaminases and jaundice, in rare cases - C Stevens-Johnson. faecalis) and pneumococcus; m / s with moderate sensitivity: Human Leukocyte Antigen gram (-) bacteria that can form spores, including Bacteroides spp., Fusobacterium spp.; Anaerobic gram (+) bacteria that form spores, including Clostridium spp.; Resistant m / s or m / s with low sensitivity, including Str. faecalis, Neisseria, most strains of Haemophilus influenzae, Pseudomonas and other perspective (-) m / s, although the genus Shigella Varicella Zoster Virus resistant to Lincomycin in vitro, the drug is effective in this disease due to the fact that in the intestine reached a very high level; observed cross-resistance between linkotsynom klindamitsynom and on one side and macrolides (erythromycin, spiramycin and perspective - on the other hand, and between linkotsynom and klindamitsynom.
